Title page for ETD etd-04042005-144815

Type of Document

Thesis

Author

Mummadavarapu, Srilakshmi

Author's Email Address

msrilu@hotmail.com

URN

etd-04042005-144815

Title

Mathematical Modeling of Blood Coagulation System with Direct Thrombin Inhibitors for Use in Anticoagulant Therapy

Degree

Master of Science

Department

Chemical Engineering, Department of

Advisory Committee

Advisor Name	Title
Dr.Srinivas Palanki	Committee Co-Chair
Dr.Yousef Haik	Committee Co-Chair
Dr. Ching-Jen Chen	Committee Member

Keywords

PT Time And INR
Direct Thrombin Inhibitors
Blood Clots

Date of Defense

2005-02-01

Availability

unrestricted

Abstract

Heart related diseases have been the leading cause of death in the United States. Approximately 29% of patients die within 1 year after an initial stroke. Anticoagulants have been prescribed to prevent many thrombotic disorders to occur. Anticoagulants have a narrow therapeutic range and the response to a standard dose varies widely both between patients and within patients over time. Changes in patient health, lifestyle or diet can effect changes in the action of the medication. Therefore, patients undergoing oral anticoagulant therapy must have their level of anticoagulation monitored frequently, with dosage adjustment as needed to ensure maximum safety and efficacy.

Mathematical models have been predicted to understand the pharmacokinetic behavior of some of these anticoagulant drugs. These models can help in proper monitoring of the drug during anticoagulation therapy. In this work we analyze the dynamics of two basic models which describe the blood coagulation system – The Extrinsic and Intrinsic pathways. The effect of direct thrombin inhibitors on clot formation is studied. With the help of these models we can predict the type of clotting factor disorder the patient is suffering from and the amount of dosage that is to be given.

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