Type of Document	Thesis
Author	Saadat, Raz L.
Author's Email Address	rls06g@fsu.edu
URN	etd-04152010-225439
Title	The Efficacy of Dried Plum in Modulating Biomarkers of Bone Turnover in Postmenopausal Women
Degree	Master of Science
Department	Nutrition, Food, and Exercise Science, Department of
Advisory Committee	Advisor Name Title Bahram H. Arjmandi Committee Chair Gershon Tenenbaum Committee Member Maria Spicer Committee Member
Keywords	Dried Plum Bone Women Osteoporosis
Date of Defense	2010-03-05
Availability	unrestricted
Abstract Previous studies from our lab suggest that dried plum may exert positive effects on biomarkers of bone turnover in animal studies and a short-term clinical trial. Dried plum is not only a rich source of vitamins, minerals and polyphenols, but has been reported as having high antioxidant properties that may be responsible in prevention of bone loss. The purpose of this study was to examine the effect of three-month dried plum consumption on the biomarkers of bone turnover in postmenopausal women. A total of 123 postmenopausal women experiencing mild bone loss and who were free of hormone replacement therapy were randomly assigned to consume either 100 grams of dried plum or a nutritional equivalence of dried apple for three consecutive months. Bone-specific alkaline phosphatase (B-SAP), osteocalcin (OC), tartrate-resistant acid phosphatase-5b (TRAP5b), and deoxypyridinoline (Dpd) were analyzed at baseline and after three months to test the effect of daily consumption of dried plum on bone turnover markers. Repeated measures (RM) multiple analysis of variance (ANOVA) followed by RM ANOVA were conducted to analyze the results. Findings of this study indicated no significant differences between the dried plum and dried apple groups when the data were analyzed considering treatment by time interaction. However, treatment by dried plum increased Dpd, while time decreased TRAP5b and increased OC in the dried plum group. The inconsistency between markers of resorption, Dpd and TRAP5b, as well as discrepancies between our findings and previous studies suggests that blood and serum markers cannot be used to predict the effect of dried plum on bone density unless bone mineral density (BMD) is measured as the end point variable that would require study duration of at least six months and preferably longer.
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