Type of Document	Dissertation
Author	Gobrogge, Kyle Lynn
Author's Email Address	gobrogge@neuro.fsu.edu
URN	etd-07022010-125443
Title	Neurobiology of Aggression in Monogamous Male Prairie Voles
Degree	Doctor of Philosophy
Department	Psychology, Department of
Advisory Committee	Advisor Name Title Zuoxin Wang Committee Chair Elaine Hull Committee Member Michael Meredith Committee Member Jon Maner University Representative Tom Keller University Representative
Keywords	Pharmacology Behavioral Neuroscience Viral Vector Vasopressin Neurobiology Hypothalamus Social Behavior
Date of Defense	2010-05-06
Availability	unrestricted
Abstract Using the well-established prairie vole (Microtus ochrogaster) model, my dissertation has explored the underlying neurochemical mechanisms regulating social behavior. In this dissertation I begin with describing the prairie vole model and reviewing the underlying neurochemical mechanisms of pair bonding and interactions between drug abuse and social behavior. Chapter 2 indentifies a sub-nucleus in the forebrain, the anterior hypothalamus (AH) that is behaviorally- and site-specifically activated during aggression. Chapter 3 demonstrates AH-vasopressin (AVP)-receptor expression and -release patterns directly regulating aggression associated with pair bonding or drug experience. Chapter 4 reveals a specific neuroanatomical circuit connecting the AH with the lateral septum, nucleus accumbens, and medial amygdala to coordinate social recognition, motivation, and behavioral expression associated with pair bonding-induced selective aggression. Finally, chapter 5 summarizes the data collected in this dissertation and discusses potential implications of these data as well as future studies in the neurobiology of aggression.
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