Type of Document Thesis Author Kitchen, Jacqueline R. Author's Email Address email@example.com URN etd-11092006-150636 Title Cloning and Expression of Notch ELRs 10-13 and Delta EBD Degree Master of Science Department Chemistry and Biochemistry, Department of Advisory Committee
Advisor Name Title John Dorsey Committee Member Nancy Greenbaum Committee Member Timothy Logan Committee Member Keywords
- Protein Expression
Date of Defense 2006-11-08 Availability unrestricted AbstractNotch signaling plays an important role in tissue differentiation and remodeling and has been extensively studied. Much has been learned about the Notch signaling pathway and consequences of defects within the path, yet little is understood about the structure and biochemistry of the Notch receptor/Notch ligand interaction responsible for initiating the signaling events.
Our goal is to investigate the biophysical interactions of Notch with its ligands Delta and Serrate. Here we describe the cloning and expression of Drosophila Notch ELRs 10-13 and Delta EBD, as well as initial isolation schemes for a Delta EBD-His construct.
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