Type of Document	Thesis
Author	Lawrence, Tait
Author's Email Address	tlawrence@fsu.edu
URN	etd-11102008-112345
Title	Does Baseline HDL-C Influence the Dose and Response Relationship Between Acute Exercise and Post-exercise HDL-C Improvement?
Degree	Master of Science
Department	Nutrition, Food, and Exercise Science, Department of
Advisory Committee	Advisor Name Title Robert J. Moffatt Committee Chair Lynn B. Panton Committee Member Laurie M. Grubbs Outside Committee Member
Keywords	Blood Lipids High Density Lipoprotein Acute Exercise Cholesterol
Date of Defense	2008-10-07
Availability	unrestricted
Abstract Does Baseline HDL-C Influence the Dose and Response Relationship Between Acute Exercise and Post-exercise HDL-C Improvement? Purpose: The purpose of this study was to determine if high density lipoprotein cholesterol (HDL-C) status (low vs. normal) affects the magnitude of post-exercise HDL-C changes over a 24 hour period and whether different caloric expenditures (300, 500 and 700 kcals) augment this relationship. Methods: Two groups of healthy untrained male volunteers participated in this study. Subjects were assigned to one of two groups based upon their resting HDL-C level. The LOW HDL-C group consisted of 13 subjects with clinically low HDL-C (< 40mg/dl) and the NORMAL HDL-C group consisted of 14 subjects with normal HDL-C (≥ 45mg/dl). Age, diet, VO2max and anthropometric data were collected prior to initiation of the experimental protocol and were similar for both groups. The characteristics of the LOW group were 21.9 ± 2.0 yrs of age, 1.8 ± 0.1 m tall, weighed 80.9 ± 7.9 kg, and had a BMI of 25.2 ± 2.2 kg/m2, a VO2max of 45.8 ± 5.1 ml/kg/min and a resting HDL-C of 35.7 ± 2.7 mg/dl. Characteristics of the NORMAL group were 23.4 ± 7.1yrs of age, 1.8 ± 0.1 m tall, weighed 78.6 ± 7.6 kg, and had a BMI of 24.3 ± 2.5 kg/m2, a VO2max of 47.5 ± 4.8 ml/kg/min and a resting HDL-C of 53.9 ± 5.8 mg/dl. Subjects randomly completed three nonconsecutive exercise trials (300, 500, and 700 kcals) on a treadmill at 65% of VO2max. Blood samples were collected pre-exercise (PRE), immediately post-exercise (IP), and 24 hours post-exercise (+24). Each sample was analyzed for HDL-C and its subfractions (HDL2-C and HDL3-C) and was corrected for plasma volume shifts. Results: There was no significant main effect of group or condition (kcal expenditure) and no interactions among variables. HDL3-C increased significantly IP regardless of group or caloric expenditure, but was not different from PRE at +24. HDL-C increased (5.6%) significantly IP regardless of group when the 500 and 700 kcal trials were combined, again the effect was transient. Individually, no caloric expenditure produced HDL-C or subfraction changes that were significantly different from one another. Conclusions: Baseline HDL-C status had no significant effect on the magnitude of post-exercise HDLC alterations. Furthermore, post-exercise improvements of HDL-C in untrained men occur via increases in HDL3-C and primarily at caloric expenditures above 300 kcals.
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