Type of Document	Thesis
Author	Messina, Michelina Marie
Author's Email Address	messina@neuro.fsu.edu
URN	etd-11142005-155557
Title	Physiological and Behavioral Effects of Acute and Chronic Administration of Melanin-Concentrating Hormone (MCH)
Degree	Master of Science
Department	Psychology, Department of
Advisory Committee	Advisor Name Title Robert J. Contreras Committee Chair Lisa A. Eckel Committee Co-Chair Mike J. Overton Committee Co-Chair Barbara Licht Committee Member
Keywords	Estrogen; Meal Size; Neuropeptide; Water Intake; F
Date of Defense	2005-10-21
Availability	unrestricted
Abstract The hypophagic effect of the ovarian hormone estradiol appears to be mediated by its ability to interact with multiple hormone, neuropeptide, and neurotransmitter systems implicated in the direct control of food intake. Nonetheless, the extent to which each individual compound contributes to the hypophagic effect of estradiol is not known. Part one of this report will examine the extent to which estradiol modulates the orexigenic effect of MCH. In addition, increasing evidence exists supporting a role for MCH in regulating energy homeostasis and autonomic activity. Nonetheless, the cardiovascular and metabolic effects of chronic MCH have not yet been established. Thus, part two of this report will examine and characterize the concurrent cardiovascular, metabolic, and behavioral responses of male rats to chronic administration of MCH.
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