Type of Document	Thesis
Author	Joud, Carol H
Author's Email Address	carol_joud@hotmail.com
URN	etd-11152005-144557
Title	Towards a New Pathway for Synthesis of Taxol and its Analogs
Degree	Master of Science
Department	Chemistry and Biochemistry, Department of
Advisory Committee	Advisor Name Title Robert A. Holton Committee Chair Marie Krafft Committee Co-Chair Joseph Schlenoff Committee Member
Keywords	Total Synthesis Meerwein-Wagner Rearrangement Oxy-Cope Reaction Taxol Analogs Taxol
Date of Defense	2005-11-14
Availability	unrestricted
Abstract The total synthesis of taxol has been attempted and successfully completed by many well known chemists. However, the access to analogs is still limited, and the complex structure of the ABC skeleton of taxol does not allow much flexibility for substitution. As a result, this thesis has been initiated in an attempt to find a more efficient pathway to access taxol analogs. Based on a former synthetic procedure, some studies have been undertaken to incorporate the C ring early in the synthesis. If successful, the ABC skeleton could be accessible in about 15 steps, and analogs could be formed through substitution at an early stage.
Files	Filename       Size       Approximate Download Time (Hours:Minutes:Seconds)     28.8 Modem   56K Modem   ISDN (64 Kb)   ISDN (128 Kb)   Higher-speed Access    MastersThesis.pdf 3.75 Mb 00:17:21 00:08:55 00:07:48 00:03:54 00:00:20