Type of Document Thesis Author Bograd, Benjamin Asher URN etd-11162004-220845 Title Cardiac Fatigue following Successive Bouts of Prolonged Endurance Exercise Degree Master of Science Department Nutrition, Food, and Exercise Science, Department of Advisory Committee
Advisor Name Title Robert J. Moffatt Committee Chair Emily Haymes Committee Member Laurie Grubbs Committee Member Keywords
- HSP 70
- Heat Shock Protein
- Consecutive Bouts
- Prolonged Endurance Exercise
- Myocyte Damage
Date of Defense 2004-10-11 Availability unrestricted AbstractThe purpose of this study was to examine cardiac function during three consecutive bouts of prolonged endurance exercise (PEE) in healthy collegeaged males for the determination of cardiac myocyte damage indicative of cardiac fatigue. Additionally, multiple bouts were performed in order to examine the cardioprotective effect of exercise and ascertain whether preconditioning was induced. In order to avoid the limitations of previous studies, the exercise sessions were completed in a controlled laboratory setting at a predetermined intensity. Likewise the 3rd generation cTnT ELISA was used in order to validate previous positive results.
The present study involved ten male, untrained runners (VO2 max 50.7 ± 3.8 ml/kg/min). During the experimental phase, subjects completed three
consecutive treadmill runs to exhaustion separated by twenty-four hours. The average total exercise time for the three bouts combined was 204.5 ± 71.49 minutes and the individual exercise bout times were 70.6 ± 31.44, 70.0 ± 25.39,
and 63.90 ± 23.95 minutes respectively. The mean peak VO2 achieved during the exercise bouts was 41.9 ± 4.8 ml/kg-1/min-1 (3.4 ± 0.4 L/min-1) which is 81.92 ± 4.4% of estimated VO2 max.
Evaluation of cardiac markers and electrocardiographic data revealed no
signs of cardiac fatigue. Electrocardiographic examination focused primarily on signs of myocardial damage and ischemia (ST segment, Q wave, and T wave). Data from the present study suggests that prolonged endurance exercise does
not induce myocardial damage in healthy, untrained male subjects. The chosen intensity of 81.92 ± 4.4% of estimated VO2 max may have inhibited the completion of a duration sufficient to induce cardiac fatigue. Additionally, it can
be hypothesized that repetitive bouts of exercise did not result in a compounding effect as cardiac fatigue was not noted during any of the exercise bouts.
While no significance was found in the current study, heat shock protein 70 (Hsp 70) values increased following exercise possibly providing enhanced myocardial protection and future resistance to the damage of ischemia or
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